New research suggests that eight loss and exercise could improve ovulation in women with polycystic ovary syndrome (PCOS), a common hormone disorder that often causes infertility, Medical News Today reported.
PCOS is a condition occurs when a woman's body produces slightly higher than normal amounts of testosterone and other androgens, sex hormones associated with male traits. The resulting hormone imbalance can cause irregular or absent menstrual periods, weight gain, acne, excess hair on the face and body, or thinning hair on the scalp.
"The findings confirm what we have long suspected -- that exercise and a healthy diet can improve fertility in women who have PCOS," Richard S. Legro, one of the study's authors and vice chair of Research and Professor of Obstetrics and Gynecology and Public Health Sciences at Penn State College of Medicine, said in a statement. "Making preconception lifestyle changes is beneficial, either alone or in combination with other pretreatment options."
For the study, researchers collected and analyzed data from nearly 150 women with PCOS who either took birth control pills, underwent lifestyle modification or a combination of the two interventions for a four-month period. The participants were between the ages of 18 and 40. The women were either overweight or obese, but had no other major medical conditions. After the intervention, the participants underwent four cycles of ovulation induced by medication.
Among the 49 women assigned to the birth control intervention, five gave birth. Of the 50 women in the lifestyle intervention group, 13 delivered babies. Twelve of the 50 women in the combination group gave birth, Medical Daily reported.
Women who participated in the lifestyle modification intervention and took birth control pills were more likely to ovulate than women who were assigned to take birth control pills. In addition, women in the lifestyle and combination arms of the study had better insulin sensitivity and lower levels of triglycerides -- a type of fat found in the blood -- than women who took birth control pills.
"The research indicates preconception weight loss and exercise improve women's reproductive and metabolic health," Legro said. "In contrast, using oral contraceptives alone may worsen the metabolic profile without improving ovulation. Lifestyle change is an important part of any fertility treatment approach for women with PCOS who are overweight or obese."
The findings are detailed in The Journal of Clinical Endocrinology & Metabolism.
