For sure, the "Agents of S.H.I.E.L.D" will be very different as it premiers its fourth season, because of the time-skip scene at the final episode of the third season. The organization of events has been validated, special thanks to Sokovia Accords being seen in the "Captain America: Civil War" as well as Phil Coulson's demotion from Director to Agent (because he's basically already dead).
Life Model Decoys are going to be added on the mix as medical advancement of the science division is going to happen on the next season and if you are very much into the series, you already know that Ghost Rider is actually added up to the team, ABC reported.
In the center of things, there's also an undeniable reality that one of the shows main protagonists, Daisy. Was last seen on the run away from S.H.I.E.L.D. having gone totally rogue. Even if there wasn't a clear explanation offered at the moment, the character has apparently been into some serious issues and the most recent of which was her love interest's death, Lincoln. Provided her inhuman state, it is nearly impossible for Daisy to be following the new restrictions on superhuman.
Chloe Bennet, the actress playing Daisy, has offered some clues as to what might happen to her character in the next season. Bennet have explained that the reason why her character distanced herself from others is because she wanted to protect them, provided that everyone whom she gotten close to have died. She further added that her character isn't necessarily trying to evolve into becoming an antagonist, but she'd like to think that being able to help is the reason why her character is doing what she is, according to Entertainment Weekly.
Although there are a lot of questions spurring in the minds of individuals, these might be answered in the upcoming premiere of "Agents of S.H.I.E.L.D". on the 20th of September on ABC.