New research suggests that a toxin known for reducing facial wrinkles may also prevent irregular heart rhythms when injected into fat surrounding the heart after bypass surgery, UPI reported.
Researchers found that when a small amount of Botox is injected into a muscle, it blocks nerve signals that tell muscles to contract. Atrial fibrillation (also called AFib or AF) is a quivering or irregular heartbeat (arrhythmia) that can lead to blood clots, stroke, heart failure and other heart-related complications.
"About a third of all patients undergoing bypass surgery will develop atrial fibrillation, putting them at higher risk for cardiovascular complications," Jonathan S. Steinberg, senior study author and Adjunct Professor of Medicine at the University of Rochester and Director of the Arrhythmia Institute in the Valley Health System, said in a statement. "Atrial fibrillation is also always associated with lengthened hospitalization and that means increased healthcare costs."
In two Russian hospitals, researchers randomly assigned 60 patients to receive Botox or saline injections. The injections were made in the four major fat pads surrounding the heart. To avoid bias, neither patients nor doctors knew whether the injections contained Botox or saline.
They found that in the 30 days following surgery, those who received Botox injections during heart bypass surgery had a 7 percent chance of developing AF, compared to 30 percent chance in patients who received saline. One year after surgery, none of the patients who received Botox had AF, compared to 27 percent of the patients who received saline. No complications from the Botox injections were reported. But complications from the bypass surgery were similar in both groups, including time in intensive care and on a breathing machine, and infection rate.
"We believe this finding may be relevant to other forms of atrial fibrillation," Steinberg told Time. "Our patients all had atrial fibrillation prior to surgery and demonstrated long-lived atrial fibrillation reduction...extending out to one year."
The findings are detailed in the journal Circulation: Arrhythmia and Electrophysiology.