Men and women have different reactions to mental stress, according to a recent study.

Researchers from the American College of Cardiology found that the impact of mental and physical stress varies differently between men and women who have stable heart disease. They have difference cardiovascular and psychological reactions.

"The relationship between mental stress and cardiovascular disease is well known," Zainab Samad, lead author of the study, said in a statement. "This study revealed that mental stress affects the cardiovascular health of men and women differently. We need to recognize this difference when evaluating and treating patients for cardiovascular disease."

For the study, researchers looked at 56 women and 254 men diagnosed with heart disease enrolled in a larger REMIT study of the impact of the medication escitalopram on heart disease induced by mental stress.

After undergoing baseline testing, participants carried out three mentally stressful tasks -- a mental arithmetic test, a mirror tracing test, and an anger recall test -- followed by a treadmill exercise test. During mental stress tasks and rest periods between tests, researchers conducted echocardiography to study changes in the heart, took blood samples, and measured blood pressure and heart rate.

The research team found that while men had more changes in blood pressure and heart rate in response to the mental stress, more women experienced myocardial ischemia, decreased blood flow to the heart. Women also experienced increased platelet aggregation, which is the start of the formation of blood clots, more than men. The women compared with men also expressed a greater increase in negative emotions and a greater decrease in positive emotions during the mental stress tests.

"At this point, further studies are needed to test the association of sex differences in the heart's responses to mental stress and long term outcomes," Samad said. "This study also underscores the inadequacy of available risk prediction tools, which currently fail to measure an entire facet of risk, i.e. the impact of negative physiological responses to psychological stress in both sexes, and especially so among women."

The findings were published in the Journal of the American College of Cardiology.