The key to a more youthful immune system might already be in your medicine cabinet.

Researchers found that over-the-counter pain reliever may restore immune function in old age. A mice study showed that macrophages from the lungs of old mice had different responses to Mycobacterium tuberculosis than macrophages from young mice, but these changes were reversed by ibuprofen.

"Inflammation in old age can have significant consequences on immune function," said Joanne Turner, a researcher involved in the work from the Department of Microbial Infection and Immunity and Center for Microbial Interface Biology at The Ohio State University. "With this knowledge, it may be possible to reduce or prevent some diseases in the elderly by decreasing inflammation with diet, exercise and/or drugs."

For the study, scientists measured inflammatory markers in the total lung or within purified macrophage populations of young healthy mice and of old healthy mice. Inflammatory markers were elevated in old mice, and isolated macrophages from both old and young healthy mice responded differentially to infection with Mycobacterium tuberculosis in vitro.

The findings suggest that the altered interactions with M. tuberculosis were linked to inflammation in old age. The researchers then placed a group of old, but healthy, mice on an ibuprofen supplemented diet, and this reduced inflammation and restored immune function to that of young healthy mice.

The findings were recently published in the Journal of Leukocyte Biology.

"This may give new meaning to the phrase 'take two aspirins and call me in the morning,'" John Wherry, Deputy Editor of the Journal of Leukocyte Biology, said in a statement. "The report may not be about aspirin, but it does show that over-the-counter remedies may broader value that usually appreciated, including by affecting immune functions that change with age."