Keeping Cool Could Spur Metabolic Benefits
ByCool environments may spur metabolic benefits, according to a recent study.
Researchers found that ambient temperatures can influence the growth or loss of brown fat in people. While cool environments stimulate growth, warm environments stimulate loss.
Brown fat, also known as brown adipose tissue, is a special kind of fat that burns energy to generate heat. It keeps small animals and babies warm, and animals with abundant brown fat are protected from diabetes and obesity. How brown fat is regulated in people, and how it relates to metabolism, have been unclear.
Previous studies have shown that people with plentiful brown fat stores tend to be lean and have low blood sugar levels. His studies have also shown -- in the laboratory -- that ordinary human white fat cells can change into brown fat cells.
For the study, five healthy men were recruited and exposed to four month-long periods of defined temperature -- well within the range found in climate-controlled buildings -- at the NIH Clinical Centre. They lived their normal lives during the day, and returned each night to the center, staying for at least 10 hours in a temperature-regulated room.
For the first month, the NIH rooms were maintained at 24º C, a 'thermo-neutral' temperature at which the body does not have to work to produce or lose heat. The temperature was then moved down to 19º C for the second month, back to 24º for the third month, and up to 27º for the fourth month.
"The big unknown until this study was whether or not we could actually manipulate brown fat to grow and shrink in a human being," researcher Paul Lee said in a study. "What we found was that the cold month increased brown fat by around [30 to 40 percent]."
During the second thermo-neutral month at 24 degrees, the brown fat dropped back, returning to baseline.
"When we put the temperature up to 27 degrees during the fourth month, the volume of brown fat fell to below that of baseline," Lee said.
Researchers said they see promise in brown fat for people with diabetes, whose bodies have to work hard to bring sugar levels down after a meal.
"The improvement in insulin sensitivity accompanying brown fat gain may open new avenues in the treatment of impaired glucose metabolism in the future. On the other hand, the reduction in mild cold exposure from widespread central heating in contemporary society may impair brown fat function and may be a hidden contributor to obesity and metabolic disorders," Lee said.
So in addition to unhealthy diet and physical inactivity, "it is tempting to speculate that the subtle shift in temperature exposure could be a contributing factor to the rise in obesity," Lee concluded.
The findings were recently presented at ICE/ENDO 2014, the joint meeting of the International Society of Endocrinology and the Endocrine Society in Chicago,